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In the eye, proteins such as lysozyme and lactoferrin can be found in two states (native and denatured):

  • Proteins in their native state act as the eye’s inborn germ-fighters, carrying out antimicrobial activity on their own
  • Proteins that are denatured have lost their structure due to factors such as external stresses

Biotrue multi-purpose solution is specially formulated to help keep native proteins active longer. It lifts and dissolves denatured proteins.

Biotrue surrounds and protects lysozyme to:

  • Maintain its natural antimicrobial activity
  • Prevent denaturation

Biotrue solution keeps more lysozyme active

In fact, Biotrue keeps more lysozyme active than any other solution1

Maintains over 13 times more active lysozyme than other solutions.


1 Results of in vitro study evaluating the ability of various multi-purpose solutions (Biotrue, AMO COMPLETE Easy Rub, Alcon OPTI-FREE Express, and Alcon OPTI-FREE RepleniSH) to stabilize lysozyme in the native form under chemical denaturation conditions that typically denature lysozyme. Solutions containing lysozyme were exposed to sodium dodecyl sulfate. Subsequently, activity against Micrococcus luteus was evaluated to assess the ability of solutions to protect lysozyme. Clear Care results from separate in vitro study performed following identical test procedures.

2 Results from a 14-investigator, multi-site clinical study in which a total of 361 subjects were enrolled wearing silicone hydrogel lenses (Bausch + Lomb PureVision® contact lenses, Vistakon ACUVUE Oasys, and CIBA O2OPTIX or CIBA Night & Day). Subjects were randomly dispensed Biotrue or OPTI-FREE RepleniSH at an approximately equal ratio. Upon study completion (two weeks) assessments were measured using a six-point Likert Scale in which 1 = strongly disagree and 6 = strongly agree. Results represent reported percentage agreement ratings.

Biotrue MPS - Lenses feel clean throughout the day
90% of patients say Biotrue solution keeps their lenses feeling clean throughout the day.2