Rx Pharmaceuticals

Zylet®: Tobramycin - Proven Antibiotic Efficacy

The aminoglycoside tobramycin is effective against a broad range of ocular pathogens. In vitro studies have demonstrated that tobramycin is active against the susceptible strains of the microorganisms shown below.^3,27,28

Common Ocular Bacterial Pathogens That Respond to Tobramycin:

Staphylococci including S. aureus and S. epidermidis (coagulase-positive and coagulase-negative), including penicillin-resistant strains.
Streptococci, including some of the Group A-beta-hemolytic species, some nonhemolytic species, and some Streptococcus pneumoniae strains.
Pseudomonas aeruginosa
Escherichia coli
Klebsiella pneumoniae
Enterobacter aerogenes
Proteus mirabilis
Morganella morganii
Proteus vulgaris (most strains)
Haemophilus influenzae
Haemophilus aegyptius
Moraxella lacunata
Acinetobacter calcoaceticus
Neisseria (some species)

In a trial investigating in vitro susceptibility of ocular pathogens, topical aminoglycosides were reported to have good corneal penetration.²¹ Compared with the topical aminoglycoside gentamicin, topical tobramycin was more effective against Pseudomonas infections.^21,
22

Tobramycin 0.3% ophthalmic solution is generally safe and well tolerated.

Topical administration of tobramycin 0.3% ophthalmic solution
results in minimal systemic absorption. Serum concentrations of
tobramycin 0.3% ophthalmic solution are low.³⁰