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MACUGEN (pegaptanib sodium injection)


What is the difference between wet and dry AMD?


Wet AMD starts out as dry AMD. Dry AMD is the early form in which proteins build up in the retina. Scientists think that the body recognizes that the dry AMD is disrupting the circulation of blood in the eye, preventing oxygen and nutrients from reaching the retina. In response, a growth factor is triggered, which causes blood vessels to grow in the eye, leading to wet AMD.


How common is wet AMD?


AMD is a progressive eye condition affecting more than 2 million Americans and millions more around the world. Although just 10% to 15% of AMD cases are the wet type, these cases account for 90% of all vision loss caused by AMD.


How do I know I need MACUGEN?


Your doctor will work with you to determine if MACUGEN is an appropriate treatment for you. For more information, speak with your doctor.


Can MACUGEN cure wet AMD?


There is currently no cure for wet AMD. Wet AMD is a serious condition that can progress to a loss of your central vision. With treatment, this loss of vision can often be slowed.


What are the most common side effects with MACUGEN?


The following side effects were reported by 10% to 40% of patients treated with MACUGEN for up to two years in clinical studies: eye swelling, blurred vision, cataract, increased redness in the white of the eye, discharge from the eye, eye irritation, eye pain, high blood pressure, increased eye pressure, eye discomfort, visual disturbances, burning sensation, redness, light sensitivity, and vision loss.

Eye injections may have side effects. Be sure to ask your retina specialist about these before treatment.


How is MACUGEN administered and how often?


MACUGEN is given by eye injection. Your doctor will schedule eye injections every 6 weeks or will customize a maintenance schedule based on your needs. In the days following MACUGEN administration, you may be at risk for the development of endophthalmitis (inflammation of the inner coats of the eye due to an infection). If the eye becomes red, sensitive to light, painful, or develops a change in vision, contact your doctor immediately so you can be treated early if an infection occurs.


What if I need help with the cost of MACUGEN?


The Focus on Access (FOA) program is a valuable resource for eligible patients and may help you with the cost of your MACUGEN treatment.

  • FOA can help eligible patients secure access to MACUGEN
  • Patients may also receive reimbursement counseling
  • Patients and physicians complete a form and FOA will provide a timely response


TO LEARN MORE call the FOCUS ON ACCESS™ Hotline, 1.866.272.8838


What can I do after treatment to ensure my wet AMD doesn’t get worse?


Treatment with MACUGEN may improve your wet AMD, but you can take steps to make sure you are getting the most out of treatment. The following are risk factors you can control:

  • Smoking – Smoking increases your risk of developing AMD, especially if AMD runs in your family.
  • Diet – A poor diet, low in antioxidants and high in saturated fats and processed foods, can increase your risk of developing AMD.
  • Obesity – People who are very overweight have a higher risk of AMD.
  • Exercise – A sedentary lifestyle contributes to the development of AMD.
  • Cholesterol – Having high cholesterol is bad for your eyes and your heart.
  • Blood Pressure – Having high blood pressure may be involved in AMD.
  • Sun Exposure – Ultraviolet and blue light from the sun and electronics can damage your eyes.

Keep up with your doctor’s plan to treat wet AMD. If anything changes, you should see your retina specialist immediately so you can be treated early.




INDICATION

MACUGEN (pegaptanib sodium injection) is approved to treat wet age-related macular degeneration, a condition that could affect your vision due to leaking blood vessels in your eye.

Important Safety Information

  • You should not receive Macugen (pegaptanib sodium injection) if you have an infection in or around your eye or if you are allergic to pegaptanib sodium or any of the other ingredients. Contact your doctor immediately if you have unusual swelling, rash, or difficulty breathing after having a Macugen injection.
  • In the days following Macugen administration, you may be at risk for the development of endophthalmitis (inflammation of the inner coats of the eye due to an infection). If the eye becomes red, sensitive to light, painful, or develops a change in vision, contact your doctor immediately so you can be treated early if an infection occurs.
  • Macugen can increase eye pressure within 30 minutes after it is injected into your eye. Your doctor may do some extra tests after your injection to make sure there are no complications or problems.
  • Serious side effects related to the injection procedure have been seen in patients receiving eye injections such as Macugen. These include endophthalmitis, a separation in the retina referred to as retinal detachment, and cataract. Less than 1% of injections have caused a serious side effect.
  • The following side effects were reported by 10-40% of patients treated with Macugen for up to two years in clinical studies: eye swelling, blurred vision, cataract, increased redness in the white of the eye, discharge from the eye, eye irritation, eye pain, high blood pressure, increased eye pressure, eye discomfort, visual disturbances, burning sensation, redness, light sensitivity, and vision loss.

Click here for Prescribing Information.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit http://www.fda.gov/medwatch or call 1-800-FDA-1088.

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